A fascinating aspect of all cells is their complex intracellular organization. Cells are subdivided in different compartments to organize cellular functions by physically separating biological reactions.
This compartmentalization is fundamental to regulate gene expression both in space and time. To understand how cells dynamically control gene expression to adapt to changing environments, we use single molecule mRNA imaging technologies both for fixed and living cells. These methods allow us to follow the entire mRNA life cycle, from transcription to degradation and from the nucleus to the cytoplasm. Using these tools, we measure, with high spatial and temporal resolution, each stage of gene expression and their coordination, to understand how single cells tune gene expression to improve their fitness. By looking at single cells, we assess how gene expression noise and cell-to cell variability affect cellular functions.
Systems Biology Lab
Vrije Universiteit Amsterdam
Room O|2 01W55
De Boelelaan 1108
1081 HZ Amsterdam
2008-2013 Doctor of Philosophy, Molecular and Cellular Biology, University of Geneva, Switzerland.
2008 Master of Science, Medical and Pharmaceutical Biotechnology, University of Genoa, Italy.
2007 Bachelor of Science, Biotechnology, University of Genoa, Italy.
August 2019 – Present: Tenure-track Assistant Professor, Systems Biology Lab, Vrije University Amsterdam, Netherlands.
2014 – 2019: Postdoctoral fellow, Laboratory of Dr. Robert H. Singer Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY.
2008 – 2014: Graduate Student, Laboratory of Dr. Françoise Stutz, Department of Cellular of Geneva, Switzerland.
2005 – 2008: Undergraduate work, Laboratory of Dr. Paolo Malatesta Department Of Developmental Biology, University of Genoa, Italy.
Fellowships and awards
2018 Travel award the RNA Society.
2017 Travel fellowship Swiss National Science Foundation: RNA society meeting, Prague.
2017 Travel award by the RNA Society .
2017 Poster prize RNA meeting 2017, RNA society.
2016 Advanced Postdoctoral Fellowship, Swiss National Science Foundation, Dept. Anatomy and Structural Biology, Albert Einstein College of Medicine, USA
2015 Travel fellowship Swiss National Science Foundation: Eukaryotic mRNA processing meeting.
2019 Travel award by the RNA Society .
2014 Early Postdoctoral Fellowship, Swiss National Science Foundation, Dept. Anatomy and Structural Biology, Albert Einstein College of Medicine, USA
2011 Travel award by the RNA Society .
2011 Travel award to attend Mechanisms of Nucleocytoplasmic Trafficking, EMBO.
Robert H. Singer, Evelina Tutucci and Maria Vera “RNA TAGGING SYSTEM FOR VISUALIZATION OF SINGLE mRNA MOLECULES” Provisional application to the US Patent and Trademark Office (no. 62/487,058).